The REN-ISAC is governed by a Board, in accordance with Bylaws, and is administered by a Host Organization (Indiana University) in accordance with an Operating Agreement, and applicable law. The Board consists of a mix of two-thirds Directors elected from the Membership and Directors that may be appointed by the Board, Host, or other Sponsor Organizations that meet the standards for Board representation as established in the Bylaws. The Board was formed June 1, 2015.
Members of the 2017-2018 Board are:
Voting:
| RuthAnne Bevier | California Institute of Technology |
| Mark Bruhn | Indiana University |
| Ken Connelly | University of Northern Iowa |
| Brian Epstein, Secretary-Treasurer | Institute for Advanced Study |
| David Escalante, Chair | Boston College |
| Harry Hoffman, Vice-Chair | Harvard University |
| Paul Howell | Internet2 |
| Martin Manjak | University at Albany |
| Randy Marchany | Virginia Tech |
Ex officio (non-voting):
| Kim Milford, Executive Director | REN-ISAC |
Advisory (non-voting):
| John Kristoff, Technical Advisory Group Chair | Depaul University |
| Joanna Grama | EDUCAUSE |
| Charles Leggett, Membership Committee Chair | Georgia Tech |
| Doug Pearson, Technical Director | REN-ISAC |